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Internal Quality Control is a top priority in laboratory procedures and must even be legally in some countries. The results obtained in ABO-D grouping and RH-Kell phenotyping of patient blood, can be validated on a daily basis with the HEMA-CQI and SERA-CQI quality control. Thus the working methods and reagents used are checked and abnormalities detected (method, equipment, reagents). Corrective measures can be implemented.